Altered signal pathway in granulocytes from patients with hypercholesterolemia
نویسندگان
چکیده
منابع مشابه
Altered signal pathway in granulocytes from patients with hypercholesterolemia.
In the present study the signal transduction of the formyl-Met-Leu-Phe receptor was studied in granulocytes obtained from control subjects and patients with elevated low density lipoprotein levels. According to our results, 10 nm formyl-Met-Leu-Phe in control cells activates phospholipase C inducing a pronounced inositol phosphate production followed by a Ca(2+) signal from intracellular pools....
متن کاملGenetic Analysis of Iranian Patients with Familial Hypercholesterolemia
Background: Familial hypercholesterolemia (FH) is a frequent autosomal dominant disorder of lipoprotein metabolism. This disorder is generally caused by mutations in low-density lipoprotein receptor (LDLR), apolipoprotein B 100 (APOB), and proprotein convertase subtilisin/kexin type 9 (PCSK9) genes. In the present study, we aimed at identifying the common LDLR and APOB gene mutations in an Iran...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 1999
ISSN: 0022-2275
DOI: 10.1016/s0022-2275(20)33420-9